Tracking context-specific transcription factors regulating hox activity
نویسندگان
چکیده
منابع مشابه
HOX transcription factors in prostate cancer
BACKGROUND: The HOX genes are a family of transcription factors that help to
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Spermatozoa entering the epididymis do not exhibit progressive motility and are incapable of fertilizing an egg in vivo. They undergo maturation through a series of cellular events occurring primarily in the proximal epididymis and are stored as mature sperm in the distal epididymis (Hinton and Palladino, 1995; Turner, 1995). The epididymis consists of a single, highly convoluted duct packed wi...
متن کاملTargeting HOX transcription factors in prostate cancer
BACKGROUND The HOX genes are a family of transcription factors that help to determine cell and tissue identity during early development, and which are also over-expressed in a number of malignancies where they have been shown to promote cell proliferation and survival. The purpose of this study was to evaluate the expression of HOX genes in prostate cancer and to establish whether prostate canc...
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Brain-derived neurotrophic factor (BDNF) is an important mediator of activity-dependent functions of the nervous system and its expression is dysregulated in several neuropsychiatric disorders. Regulation of rodent BDNF neuronal activity-dependent transcription has been relatively well characterized. Here, we have studied regulation of human BDNF (hBDNF) transcription by membrane depolarization...
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Limb development, a complicated biological event that includes diverse processes such as three-dimensional patterning, cartilage and bone differentiation and programmed cell death, or apoptosis, is regulated by a network of signal molecules that work in concert to ensure proper morphogenesis. Bone Morphogenetic Proteins (BMPs), members of the TGF superfamily, play a pivotal role in the signalin...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2013
ISSN: 1058-8388
DOI: 10.1002/dvdy.24002